TOPTION INSTRUMENT CO.,LTD
TOPTION INSTRUMENT CO.,LTD
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GZLY suitable for medical and pharmaceutical vacuum freeze dryer
| Lyophilizer | GZLY-1 | GZLY-2 | GZLY-3 | GZLY-5 | GZLY-10 | GZLY-15 | GZLY-20 | GZLY-30 | GZLY-40 |
| Freeze drying area | 1.152 ㎡ | 2.16 ㎡ | 3.24 ㎡ | 5.25 ㎡ | 10.5 ㎡ | 15 ㎡ | 20.2 ㎡ | 30 ㎡ | 40 ㎡ |
| Condenser temperature | < -75℃ (no-load) | ||||||||
| Partition board temperature | ≤ -55℃ (no-load) | ||||||||
| control accuracy | ±1℃ | ||||||||
| Vacuum degree | < 5Pa (no-load) | ||||||||
| Cooling method | water cooling | ||||||||
| Water capture capacity | 20Kg/24h | 40Kg/24h | 60Kg/24h | 100kg/24h | ＞ 200kg/24h | ＞ 300kg/24h | 400kg/24h | 600kg/24h | 800kg/24h |
| Partition board size | 600 x 480 x 20mm*4+1 | 600 x 900 x 20mm*4+1 | 600 x 900 x 20mm*6+1 | 750 x 1000 x 20mm*7+1 | 1520 x 990mm*7+1 | 1520 x 990mm*10+1 | 1520 x 1210mm*11+1 | 1500 x 1800mm*11+1 | 1500 x 1800mm*15+1 |
| Installed Powe | 15kw | 15kw | 18kw | 20kw | 50kw | 83kw | 105 | 145 | 170 |
| Weight | 1500kg | 2600kg | 2800kg | 4200kg | 7000kg | 9000kg | 11000kg | 15000kg | 20000kg |
| Dimension(mm) | 2500x1100x2000 | 3500x1300x2000 | 2800x1200x2500 | 4000x1500x2500 | 6700×2100×3600 | 6500x2300x3400 | 7400x2300x3800 | 9200x2400x4000 | 9400x2400x4500 |
| Bulk capacity Thickness:10mm | 10L | 20L | 30L | 50L | 200L | 300L | 450L | 600L | 850L |
| Vial loading | Ф12mm:8400 | Ф12mm:12600 | Ф12mm:16000 | Ф12mm:35000 | Ф12mm:65300 | Ф12mm:95700 | Ф12mm:130400 | Ф12mm:187700 | Ф12mm:56000 |
| Ф16mm:4706 | Ф16mm:6800 | Ф16mm:10000 | Ф16mm:24800 | Ф16mm:46400 | Ф16mm:66400 | Ф16mm:92800 | Ф16mm:133600 | Ф16mm:82200 | |
| Ф22mm:2428 | Ф22mm:3600 | Ф22mm:5300 | Ф22mm:12700 | Ф22mm:23700 | Ф22mm:33900 | Ф22mm:47400 | Ф22mm:68300 | Ф22mm:93000 | |
GZL series vacuum freeze dryer
| Lyophilizer | GZL-1 | GZL-2 | GZL-3 | GZL-5 | GZL-10 | GZL-15 | GZL-20 | GZL-30 | GZL-40 |
| Freeze drying area | 1.152 ㎡ | 2.16 ㎡ | 3.24 ㎡ | 5.25 ㎡ | 10.5 ㎡ | 15 ㎡ | 20.2 ㎡ | 30 ㎡ | 40 ㎡ |
| Condenser temperature | < -75℃ (no-load) | ||||||||
| Partition board temperature | ≤ -55℃ (no-load) | ||||||||
| Control accuracy | ±1℃ | ||||||||
| Vacuum degree | < 5Pa (no-load) | ||||||||
| Cooling method | water cooling | ||||||||
| Water capture capacity | 15Kg/24h | 30Kg/24h | 45Kg/24h | 100kg/24h | ＞ 200kg/24h | ＞ 300kg/24h | 400kg/24h | 600kg/24h | 800kg/24h |
| Partition board size | 600 x 480 x 20mm*4+1 | 600 x 900 x 20mm*4+1 | 600 x 900 x 20mm*6+1 | 750 x 1000 x 20mm*7+1 | 1520 x 990mm*7+1 | 1520 x 990mm*10+1 | 1520 x 1210mm*11+1 | 1500 x 1800mm*11+1 | 1500 x 1800mm*15+1 |
| Installed Powe | 12kw | 14kw | 16kw | 20kw | 50kw | 75kw | 100 | 145 | 170 |
| Weight | 1200kg | 2000kg | 2800kg | 3500kg | 6500kg | 8000kg | 95000kg | 15000kg | 20000kg |
| Dimension(mm) | 2500x1100x2000 | 3500x1300x2000 | 2800x1200x2500 | 4000x1500x2500 | 6700×2100×3600 | 6500x2300x3400 | 7400x2300x3800 | 9200x2400x4000 | 9400x2400x4500 |
| Bulk capacity | 10L | 20L | 30L | 50L | 200L | 300L | 450L | 600L | 850L |
| Vial loading | Ф12mm:8400 | Ф12mm:12600 | Ф12mm:16000 | Ф12mm:35000 | Ф12mm:65300 | Ф12mm:95700 | Ф12mm:130400 | Ф12mm:187700 | Ф12mm:256000 |
| Ф16mm:4706 | Ф16mm:6800 | Ф16mm:10000 | Ф16mm:24800 | Ф16mm:46400 | Ф16mm:66400 | Ф16mm:92800 | Ф16mm:133600 | Ф16mm:182200 | |
| Ф22mm:2428 | Ф22mm:3600 | Ф22mm:5300 | Ф22mm:12700 | Ф22mm:23700 | Ф22mm:33900 | Ф22mm:47400 | Ф22mm:68300 | Ф22mm:93000 | |
CIP and SIP system freeze dryer is designed based on mature technology, use top quality material and parts which is widely accepted in pharmaceutical industry. Its manufacturing process use the most advanced technology, equipment totally meet CGMP standard, software meets 21 CFR Part 11 standard.
Freeze drying chamber is a kind of pressure vessel and products finish its vacuum freeze drying process in it. Chamber body generally use stainless steel square box, this reasonable structure design could make clean be more convenient and reduce the blind angle.
Put products in shelf, through freezing medium control temperature up/down,to achieve prefreezing and sublimation dehydration, besides, the stoppering can be fulfilled by shelves before products exiting from the chamber. Use indirect cooling and heating method. Every shelf through special design, produce and processing, so could achieve uniform cooling and heating.
Cooling system is consist of refrigerating compressor, water cooled condenser, throttle valve, evaporator,etc, provide cooling source for freeze drying chamber and vacuum condenser.
Circulating system through freezing medium to control shelf temperature, circulating pump drive freezing medium circulating.
The isolation valve allows proceeding with the product loading, unloading and freezing while the condenser is defrosted. In addition, the isolation valve can be used to test the degree of product drying by measuring the pressure rising during a preset closing time.
This system is used for feeding and discharging materials through lifting and dropping the shelves. At the same time, it is good for cleaning the chamber. Besides, the stopper can be pressed into penicillin bottle. It is also used for freezing and drying scattering material.
CIP could run automatically or manually through control program, whole sterilization process finish automatically.
Whole parts meet FDA/ CGMP standard.
GZVF series freeze dryers use double color touch screen and PLC as control center ,control system stable and reliable. it can store 33groups of freeze drying program , and each program can be set up 36 segments. It can display freeze drying curve and automatically records data.Freeze drying data can be output by USB flask disk.
GZVF series freeze dryers use Bitzer refrigeration unit,condenser temperature can reach < -75℃ , performance stable .This model is suitable for production.
| Food lyophilizer | GZVF-2 | GZVF-5 | GZVF-12 | GZVF-16 | GZVF-33 | GZVF-44 |
| Drying chamber | ||||||
| Shelf area(m 2 ) | 2.4 | 5.9 | 12 | 16 | 33 | 44 |
| Drying chamber size(m) | Φ0.75 * 0.9 | Φ1.1 * 1.2 | Φ1.4 * 1.5 | Φ1.5 * 2.1 | Φ1600 * 3600 | Φ1800 * 3600 |
| Shelf layers | 6+1 | 8+1 | 12+1 | 12+1 | 14+1 | 14+1 |
| Shelf size(mm) | 500 * 800 | 1050 * 700 | 1200 * 800 | 1800 * 800 | 3100 * 800 | 3600 * 1000 |
| Shelf spacing(mm) | 70 | 70 | 70 | 75 | 75 | 758 |
| Trolley number(set) | N/A | 1 | 2 | |||
| Trolley number(set) | N/A | 1 | 2 | |||
| Tray size(mm) | 350X500 | 350X500 | 400X600 | 400X600 | 400X500 | 400X500 |
| Trays number (pcs) | 24 | 64 | 96 | 144 | 336 | 448 |
| Heating way | heat conductive oil circulation | |||||
| Temperature range | room temperature~120 | |||||
| control accuracy | ±1℃ | |||||
| condenser | ||||||
| Max. Ice capacity Kg) | 24 | 75 | 150 | 225 | 450 | 600 |
| Ice capacity(kg/day) | 20 | 60 | 100 | 150 | 300 | 400 |
| Lowest temperature(℃) | -85 | |||||
| Temperature lowing style | direct evaporation | |||||
| Defrosting method | warm water spray | |||||
| basic parameters | ||||||
| final vacuum(Pa) | 5 | |||||
| Installed power(Kw) | 6 | 12 | 25 | 37 | 72 | 104 |
| cooling water(m3/h) | air cooling | 8 or air cooling | 15 or air cooling | 22 or air cooling | 50 | 60 |
| cooling water pipe dia | 无 N/A | 1 1/4″or N/A | 1 1/2″ or N/A | 1 1/2″ or N/A | 2″ | 2″ |
| dimension(m) | 1.5×1.5 | 3×2 | 4×2.2 | 5×2.3 | 8×2.6 | 9×3.2 |
| height(m) | 2 | 2.2 | 2.3 | 2.3 | 2.6 | 3.2 |
| weight | 1.3 | 2.5 | 4 | 6 | 15 | 20 |
Main features of food & fruit industrial freeze drying equipment:
1.Vertical cylindrical condenser,compact structure,with good water capture capacity, no dead corner, easy for defrosting and cleaning.
2. Refrigeration system protection control device: adopt international famous brand products, accurate, stable, safe and reliable.
3. High pressure protection system: when the system exhaust pressure more than allowed, refrigeration unit running will be automatically cut off , to prevent accidents.
4. Middle pressure regulation system: in the double-stage refrigeration system, proper middle pressure are very important for operation performance and life of the refrigeration system. When middle pressure below the set value, the system will automatically start to adjust. Create conditions for the realization of the lyophilizer unmanned operation.
5. Oil pressure protection system: when the long time operation of the refrigerator, monitor the hydraulic pressure of the refrigerator, prevent refrigerator damage because of oil lack.
6. The motor temperature protection system: when the refrigerator motor temperature higher than the set value, in order to protect the refrigerator, the system will automatically stop the operation of the refrigerator.
7. Oil return at low temperature regulating system: when refrigerator works under very low evaporation temperature for long time , how to make the refrigeration oil well back to the crankcase is very important (lack of refrigeration oil in the system often causes refrigerator “burned”). When the crankcase lack of refrigeration oil, the system automatically start to establish proper oil level in the crankcase. Create conditions for the realization of the lyophilizer unmanned operation.
8. Exhaust temperature control system: when refrigerator exhaust temperature is too high, the system automatically start cooling system, to prevent the high pressure part of overtemperature operation. Create conditions for the realization of the lyophilizer unmanned operation.
9. Wet stroke prevention control system: when the high load operation of the refrigerator, the system can automatically go in the process of adjustment, prevent the wet stroke even “liquid impact phenomenon”. Create conditions for the realization of the lyophilizer unmanned operation.
10. Automatic liquid collection device: when the refrigerator is in standby mode, the device will automatically run , to collect stranded refrigerant in the system to storage tank, in order to start the freeze dryer again.
11. The machine start protection: when equipment has all security conditions , the machine will be able to start running.
12. whole machine structure longitudinal, front and back split type (convenient for transport and placing ).
13. Ozone disinfection function is optional.
Customer case of freeze drying equipment
CIP and SIP system freeze dryer is designed based on mature technology, use top quality material and parts which is widely accepted in pharmaceutical industry. Its manufacturing process use the most advanced technology, equipment totally meet CGMP standard, software meets 21 CFR Part 11 standard.
Freeze drying chamber is a kind of pressure vessel and products finish its vacuum freeze drying process in it. Chamber body generally use stainless steel square box, this reasonable structure design could make clean be more convenient and reduce the blind angle.
Put products in shelf, through freezing medium control temperature up/down,to achieve prefreezing and sublimation dehydration, besides, the stoppering can be fulfilled by shelves before products exiting from the chamber. Use indirect cooling and heating method. Every shelf through special design, produce and processing, so could achieve uniform cooling and heating.
Cooling system is consist of refrigerating compressor, water cooled condenser, throttle valve, evaporator,etc, provide cooling source for freeze drying chamber and vacuum condenser.
Circulating system through freezing medium to control shelf temperature, circulating pump drive freezing medium circulating.
The isolation valve allows proceeding with the product loading, unloading and freezing while the condenser is defrosted. In addition, the isolation valve can be used to test the degree of product drying by measuring the pressure rising during a preset closing time.
This system is used for feeding and discharging materials through lifting and dropping the shelves. At the same time, it is good for cleaning the chamber. Besides, the stopper can be pressed into penicillin bottle. It is also used for freezing and drying scattering material.
CIP could run automatically or manually through control program, whole sterilization process finish automatically.
Whole parts meet FDA/ CGMP standard.